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来源:菲律宾马尼拉机场飞机滑出跑道机上人员安全撤离  作者:   发表时间:2019-12-15 09:14:44

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  Chinese scientists find how bats carry viruses without getting sick#标题分割#ChinesescientistshaveidentifiedthesecretofbatsthatharborhighlypathogenicviruseslikeEbola,MarburgandSARScoronavirusbutdonotshowclinicalsignsofdisease.InapaperpublishedonThursdayinthejournalCellHostMicrobe,scientistsattheWuhanInstituteofVirologyinChinafindthatinbats,anantiviralimmunepathwaycalledtheSTING-interferonpathwayisdampened,sobatscanmaintainjustenoughdefenseagainstillnesswithouttriggeringaheightenedimmunereaction."Webelievethereisabalancebetweenbatsandthepathogenstheycarry,"saidthepaper'sseniorauthorZhouPeng."Thisworkdemonstratedthatinordertomaintainabalancewithviruses,batsmayhaveevolvedtodampencertainpathways,"Zhousaid.Accordingtoresearchers,inhumansandothermammals,animmune-basedover-responsetooneoftheseandotherpathogenicvirusescantriggersevereillness.Forexample,inhumans,anactivatedSTINGpathwayislinkedwithsevereautoimmunediseases."Inhumanhistory,wehavebeenchasinginfectiousdiseasesoneafteranother,"saidZhou,"Butbatsappeartobea'super-mammal'tothesedeadlyviruses."ByidentifyingaweakenedbutnotdefunctSTINGpathwayinbats,researchershavesomenewinsightintohowbatsfine-tuneantiviraldefensestobalanceaneffective,butnotanovert,responseagainstviruses.Theyhypothesizethatthisdefensestrategyevolvedaspartofthreeinterconnectedfeaturesofbatbiology:theyareflyingmammals,havealonglifespan,andhostalargeviralreservoir."AdaptationtoflightlikelycausedpositiveselectionofmultiplebatinnateimmuneandDNAdamagerepairgenes,"Zhousaid.TheseadaptationsmayhaveshapedcertainantiviralpathwaysincludingSTING,interferontomakethemgoodviralreservoirhostsandachieveatolerablebalance.ZhoutoldXinhuathatthestudyhasprovidedapossibilitythatpeoplecanlearnfrombatsincombatingvirusalthoughwhetherthismechanismcanbedirectlyusedinhumansisstillunknown.  

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